Here are actionable strategies to enhance tabletability:
1. Add Excipients
1.1 Diluents
Principle: Diluents increase bulk volume, reduce interparticle friction, and improve flow/compression. For example, lactose acts as a filler, enhancing particle rearrangement under pressure. It deforms plastically, promoting cohesive bonding between drug particles.
Application: In herbal tablet formulations, adding starch reduces material looseness, enabling stable tablet formation.
1.2 Binders
Principle: Binders strengthen interparticle adhesion. Hydroxypropyl methylcellulose (HPMC) forms a cohesive film on particles, enhancing plasticity and bonding under compression.
Application: For poorly compactable vitamin C crystals, polyvinylpyrrolidone (PVP) improves tablet hardness and structural integrity.
1.3 Lubricants
Principle: Lubricants like magnesium stearate reduce friction between particles and tooling (punches/dies), preventing surface defects and tool wear.
Application: In amino acid-containing tablets, magnesium stearate enhances flow and ejection, yielding smooth-surfaced tablets.
2. Modify Particle Size/Shape
2.1 Granulation
Principle: Wet granulation aggregates fine powders into larger granules, reducing surface area and friction. This improves flow and deformation under compression.
Application: Antibiotic powders with poor compressibility are granulated to form cohesive particles for high-quality tablets.
2.2 Crystallization Optimization (for crystalline materials)
Principle: Adjusting crystallization parameters (e.g., temperature, agitation) transforms needle-like crystals into spherical shapes, improving flow and compaction.
Application: Spherical alkaloid crystals reduce tablet capping and lamination during compression.
3. Preprocess Materials
3.1 Polymorph Conversion (for polymorphic drugs)
Principle: Metastable polymorphs (e.g., via solvent-mediated or thermal methods) often exhibit better compressibility due to higher energy states.
Application: Steroid drugs converted to compressible polymorphs form robust tablets at lower pressures.
3.2 Solid Dispersion (for poorly soluble drugs)
Principle: Dispersing drugs in carriers like polyethylene glycol (PEG) or PVP reduces crystallinity, enhances surface area, and improves compressibility.
Application: Ibuprofen-PVP solid dispersions yield tablets with superior dissolution and mechanical strength.
Key Takeaways
Diluents (e.g., lactose, starch) and binders (e.g., HPMC, PVP) address poor cohesion.
Lubricants (e.g., magnesium stearate) mitigate friction-related defects.
Granulation and crystallization optimize particle properties for compression.
Polymorph control and solid dispersions enhance material compatibility with tablet presses.
本文本 是一个指向本网站中的一个页面的链接。
本文本 是一个指向万维网上的页面的链接。
